09 junio 2006

Evolución, pleitropía antagónica y Alzheimer.


Saludos,

hasta hace bien poco, he estado haciendo un trabajillo voluntario para fisio animal. El tema: Alzheimer. Es curioso, cuánto hemos oído hablar de él pero la mayoría no sabemos en qué consiste la enfermedad. El caso es que un día llegó a mis manos, gracias a mi padre, un articulito con un nombre un poco...en fin, ¿impactante quizás? Después de todo lo que llevaba leído reconozco que notaba un vacío peculiar; algo como: "Sí, todo esto, la bioquímica, la neuropatología, la genética, etc. del Alzheimer es muy interesante. Pero, ¿qué significado tiene la curiosa existencia de esta enfermedad? ¿Por qué es la demencia más común en los países "desarrollados" (perdonad por esta nefasta categoría)?
Estaba yo con las proteínas y genes, la citología e histopatología, las vías neuroquímicas,...intentando hallar un nexo de unión razonable y lógico; una explicación o justificación biológica para la EA. Entonces, como digo, cayó en mi haber este trabajo de Bufill y Blesa, que se ha convertido en una especie de golosina intelectual biológica en la que me paro a pensar a menudo.

Así os corto; no digo más para que lo leáis. Confío en que estimule vuestras neuronas tanto como a mí. Os paso el vínculo desde el que os lo podéis descargar (es un .pdf):
http://www.filelodge.com/files/hdd8/188143/Apuntes/Buffil_E.pdf

Sin más me despido por ahora,

Fernando.

140 Comentarios:

  • Buenas!! Primero de todo: Bienvenido a Doblehelice.

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    Por ahora, nada más, hasta que me pueda leer el artículo (que además para eso también hace falta tiempo. Pero bueno, tarde o temprano...caerá).

    Un saludete

    By Blogger Mannyac Boy, a las 12:04 a. m.  

  • Buenas Mannyac Boy:

    ¿Nos hemos presentado?, Yo soy Fernando Josa del grupo 32.

    Te voy a enviar un mail con el artículo. No se por qué no podrás...a mí sí me funciona.

    Un saludo

    By Blogger Phernael, a las 12:49 a. m.  

  • Por cierto, en el otro post te he contestado, y no me he presentado. Soy Manny, un colega de Gon, Djordje, etc etc etc... de cuarto, así que creo que no nos conocemos aún. Pero con esto, ya están superados los formalismos.

    En cuanto al artículo, gracias, me ha llegado perfectamente, así que me lo leere mañana tranquilamente cuando tenga un ratillo (que además he visto que está en español y uno, que lleva todo el año leyendo artículos en ingles, lo agradece :-D)

    Un saludete

    By Blogger Mannyac Boy, a las 1:23 a. m.  

  • Jajaja... pedazo de artículo. Más que golosina intelectual, esto es directamente pornografía científica. Madre de Dios! Si la mitad de las hipótesis que plantea llegaran a ser ciertas... agarrate.
    Por cierto, soy Leko, no había tenido oportunidad de presnetarme antes. Y gracias por el artículo. Este tipo de cosas siempre se agradece!
    Por cierto... ¿cuál es TU opinión en concreto sobre el temita?

    By Blogger Leko, a las 2:11 a. m.  

  • Muy buenas, Leko.
    ¿De veras te gustó?
    Yo soy Fernando Josa. De la mañana, G32. Un placer.

    Sinceramente, mi opinión está muy trastocada por la pasión que siento por la idea que estos señores lanzan. No sé hasta qué punto llegan tus conocimientos sobre EA. Por lo poco que yo sé sobre esta patología, me parece muy razonable lo expuesto en el artículo. No sólo lanzan la hipótesis; la apoyan en ciertos y muy relevantes conocimientos sobre fisiopatología comparada, relojes moleculares para los distintos tipos de ApoE, así como la sobreexpresión de ciertos genes de plasticidad neuronal, nuerotróficos y de neuroprotección.
    Los humanos tenemos algo que nos distingue, al menos en cuanto a nuestro cerebro. Enfermedades propias como el Alzheimer, en toda su complejidad lo demuestran. Pero averiguar lo que significa bilógicamente...eso ya es otro cantar...
    Es lo que me sorprendió de este trabajo. Me parece muy redondo. Es decir, es pequeño pero está muy bien acabado. Seguir el desarrollo del razonamiento es fácil.
    Pero si hay algo que me fascina es la elegancia de la conclusión. Y yo la elegancia científica la valoro mucho. Sencillo y potente.
    En cuanto a la implicación práctica, mucha a mi parecer. Centrarse en los mecanismos de plasticidad neuronal y del mayor desgaste que ésta implica, focalizaría mucho las dianas terapéuticas en enfermedades neurodegenerativas como la EA.

    ¿Qué es lo que más te gustó?

    (Música de Carl Off: "O Fortuna", Carmina Burana,jeje)
    ¿Pleiotropía antagónica?
    -¡¡SÍ!!¡¡!PLEIOTROPÍA ANATGÓNICA!!!

    By Blogger Phernael, a las 8:20 p. m.  

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